Basic information of OPA1 :
| Official Symbol of Gene | OPA1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4976 |
| Official Full Name | OPA1 mitochondrial dynamin like GTPase |
| Also known as | NPG; NTG; MGM1; BERHS; largeG; MTDPS14 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000198836 MIM:605290; AllianceGenome:HGNC:8140 |
| Map Location | 3q29 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | Western Blotting |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | N/A |
| Sample Size | 15 HC / 15 MS subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 32290388 |
| Year | 2020 |
| Title | PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels |
Results of multiple sclerosis :
| Expression | No significance |
| Risk type | Disease risk |
| Result | Densitometric analysis of immuno-revealed bands of OPA1 (L+S) showed the same level of total OPA1protein in MS group with respect to HC.No difference was observed in percentage of L and S form of OPA1 between HC and SM samples.No differences were observed in Rf of L-OPA1 between HC and MS samples . |
| Mechanism/Pathway | Increase of reactive oxygen species (ROS), impairment of mitochondria-mediated apoptosis and mitochondrial alterations have been reported in peripheral lymphocytes of MS patients.Mitochondria-mediated apoptosis is regulated by several mechanisms and proteins.Among others, optic atrophy 1 (OPA1) protein plays a key role in the regulating mitochondrial dynamics, cristae architecture and release of pro-apoptotic factors. |
