Basic information of PHB2 :

Official Symbol of Gene	PHB2
Species	Homo sapiens
Entrez Gene ID	11331
Official Full Name	prohibitin 2
Also known as	BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000215021 MIM:610704; AllianceGenome:HGNC:30306
Map Location	12p13.31

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	Western Blotting
Disease	MS
Disease subtype	RRMS, SPMS
Population	N/A
Sample Size	15 HC / 15 MS subjects

Literature information of multiple sclerosis :

Pubmed ID	32290388
Year	2020
Title	PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	An increased PHB2 protein level was observed in MS patients.
Mechanism/Pathway	OPA1 stability is controlled by prohibitin 2 (PHB2) a chaperon like protein, localizes in nucleus, plasma membrane, and mitochondria.Evidences indicate that mitochondrial PHB2 is over expressed under conditions of oxidative stress.