Basic information of SIRT3 :
| Official Symbol of Gene | SIRT3 |
| Species | Homo sapiens |
| Entrez Gene ID | 23410 |
| Official Full Name | sirtuin 3 |
| Also known as | SIR2L3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000142082 MIM:604481; AllianceGenome:HGNC:14931 |
| Map Location | 11p15.5 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | Western Blotting |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | N/A |
| Sample Size | 15 HC / 15 MS subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 32290388 |
| Year | 2020 |
| Title | PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels |
Results of multiple sclerosis :
| Expression | No significance |
| Risk type | Disease risk |
| Result | No difference was observed for SIRT3 protein level. |
| Mechanism/Pathway | OPA1 processing is also modulated by its acetylation status mediated by SIRT3 enzyme, a mitochondrial deacetylase that also plays an important role in apoptosis . |
