Basic information of MMP2 :

Official Symbol of Gene	MMP2
Species	Homo sapiens
Entrez Gene ID	4313
Official Full Name	matrix metallopeptidase 2
Also known as	CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000087245 MIM:120360; AllianceGenome:HGNC:7166
Map Location	16q12.2

Sample information of multiple sclerosis:

Detected Sample	serum
Sample Detail	N/A
Detected Method	ELISA
Disease	MS
Disease subtype	RRMS, SPMS, PPMS
Population	N/A
Sample Size	87 MS patients / 50 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	19153173
Year	2009
Title	Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Phenotypic risk
Result	A significant elevation in MMP-2 serum levels was observed in the primary progressive and the SPMS groups when compared with the RRMS group, and this increase was also associated with the disability and severity of the disease.
Mechanism/Pathway	Matrix metalloproteinases (MMPs) play an important role in the immunopathogenesis and progression of disease. It has been suggested that an imbalance between MMP and TIMP expression may lead to persistent proteolytic activity with subsequent continuous tissue destruction in various diseases, including MS. In the immunopathogenesis of MS, metalloproteinases are involved in the disruption of the blood-brain barrier (BBB), invasion of immune cells into the CNS parenchyma, degradation of the basic myelin protein, and direct neurotoxicity.