Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | polymorphism |
| refSNP ID | TNF2 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS,PPMS |
| Population | Croatian and Slovenian |
| Sample Size | 338 patients and 460 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17268200 |
| Year | 2007 |
| Title | Tumor necrosis factor-alpha-308 gene polymorphism in Croatian and Slovenian multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | phenotypics risk |
| Main Result | Negative |
| Result | No significant differences were observed when the 3 MS subtypes were compared to each other. |
| Mechanism/Pathway | Which also suggested that heterozygosity for the rare TNF2 allele, that is, the A/G genotype, confers protection against MS. |
