Basic information of SEMA3A :
| Official Symbol of Gene | SEMA3A |
| Species | Homo sapiens |
| Entrez Gene ID | 10371 |
| Official Full Name | semaphorin 3A |
| Also known as | HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000075213 MIM:603961; AllianceGenome:HGNC:10723 |
| Map Location | 7q21.11 |
| Variation Type | SNP |
| refSNP ID | rs740948A |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | Ninety-nine PMS and 214 RRMS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 33864731 |
| Year | 2021 |
| Title | Assessment of the genetic contribution to brain magnetic resonance imaging lesion load and atrophy measures in multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | For RRMS, clustering of phenotypes revealed hierarchically grouped associations for the GM volumetric measures driven by variants in SEMA3A and GRIN2B loci, with evidence of association between rs740948A in SEMA3A and higher WMV, whereas the variant rs7970177T in GRIN2B is associated with decreased volume of deep GM. |
| Mechanism/Pathway | N/A |
