Basic information of APOA1 :
| Official Symbol of Gene | APOA1 |
| Species | Homo sapiens |
| Entrez Gene ID | 335 |
| Official Full Name | apolipoprotein A1 |
| Also known as | HPALP2; apo(a) |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000118137 MIM:107680; AllianceGenome:HGNC:600 |
| Map Location | 11q23.3 |
| Variation Type | allel |
| refSNP ID | A |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood leukocytes |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS,PPMS |
| Population | N/A |
| Sample Size | 138 patients with MS and 43 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 18805838 |
| Year | 2009 |
| Title | An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | APOA1 A-allele carriers displayed superior overall cognitive performance compared with non-carriers (P 0.008) and had a three-fold decrease in the relative risk of overall cognitive impairment. |
| Mechanism/Pathway | With decreased reverse cholesterol transport from brain to periphery possibly leading to cerebral cholesterol accumulation favoring amyloidogenesis, elevated ApoA1 levels may act in a protective fashion. |
