Basic information of BIRC5 :
| Official Symbol of Gene | BIRC5 |
| Species | Homo sapiens |
| Entrez Gene ID | 332 |
| Official Full Name | baculoviral IAP repeat containing 5 |
| Also known as | API4; EPR-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089685 MIM:603352; AllianceGenome:HGNC:593 |
| Map Location | 17q25.3 |
| Variation Type | SNP |
| refSNP ID | rs9904341 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 200 RRMS patients,200 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31438837 |
| Year | 2019 |
| Title | Genetic polymorphisms and epigenetic regulation of survivin encoding gene, BIRC5, in multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | phenotypics risk |
| Main Result | Positive |
| Result | It was observed that the C allele (OR = 1.38, 95% CI = 1.05–1.348, P = 0.022) and CC genotype (OR = 1.84,95% CI = 1.06–3.19; P = 0.029) in the rs9904341 polymorphism increased the disease risk. |
| Mechanism/Pathway | The rs9904341 SNP was associated with increased mRNA and protein expressions of survi vin in cancers. |
