Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID |
HLA-DRB1*15:01( |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | RRMS;PMS;EDSS |
| Population | Japanese patients |
| Sample Size | 66 patients with MS (50 relapsing remitting, 16 progressive) |
Literature information of multiple sclerosis :
| Pubmed ID | 32247967 |
| Year | 2020 |
| Title | Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | disease risk |
| Main Result | Positive |
| Result | Our study suggests that distinct HLA-DRB1 alleles could differentially influence brain and lesion volumes over the disease course of MS. |
| Mechanism/Pathway | HLA-DRB1*15 augments the extent of inflammation in cortical lesions. |
