Basic information of TGFB1 :
| Official Symbol of Gene | TGFB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 7040 |
| Official Full Name | transforming growth factor beta 1 |
| Also known as | CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000105329 MIM:190180; AllianceGenome:HGNC:11766 |
| Map Location | 19q13.2 |
| Variation Type | genotype |
| refSNP ID | DRB1*15 + TGFB1*T + CCR5*d |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-SSP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Russian |
| Sample Size | 285 Russian MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 22111603 |
| Year | 2012 |
| Title | Allelic combinations of immune-response genes associated with glatiramer acetate treatment response in Russian multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Carriers of the most significant combinations: DRB1*15 + TGFB1*T + CCR5*d + IFNAR1*G and DRB1*15 + TGFB1*T + CCR5*d (permutation p-values: 0.0056 and 0.013, respectively) had a 14 to 15-times increased risk of ineffective response to GA therapy. |
| Mechanism/Pathway | N/A |
