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Basic information of HLA-DQB1 :

Official Symbol of Gene HLA-DQB1
Species Homo sapiens
Entrez Gene ID 3119
Official Full Name major histocompatibility complex, class II, DQ beta 1
Also known as IDDM1; CELIAC1; HLA-DQB
Gene Type protein coding
dbXrefs Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944
Map Location 6p21.32
Variation Type polymorphisms
refSNP ID DQB1*0602

Sample information of multiple sclerosis:

Detected Sample venous blood
Sample Detail N/A
Detected Method N/A
Disease MS
Disease subtype N/A
Population Caucasian
Sample Size 70 Caucasian patients

Literature information of multiple sclerosis :

Pubmed ID 8244781
Year 1993
Title The influence of HLA-DR and -DQ alleles on progression to multiple sclerosis following a clinically isolated syndrome

Results of multiple sclerosis :

Risk Type Disease risk
Main Result Negative
Result Conversion to MS was positively associated with the DRB1*1501.DQA1*0102.DQBl*0602 haplotype, but the influence of HLA was only significant in patients with disseminated brain lesions at presentation (MRI positive); MS developed in 86% of MRI-positive, DRBl*1501-positive patients compared with 55% of MRI -positive, DRB 1 * 1501-negative patients.
Mechanism/Pathway N/A