Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | DNA methylation |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | real time PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 69 relapsing–remitting multiple sclerosis (RR–MS) patients and 69 age/gender-matched healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 34624384 |
| Year | 2021 |
| Title | Changes in DNA methylation in APOE and ACKR3 genes in multiple sclerosis patients and the relationship with their heavy metal blood levels |
Results of multiple sclerosis :
| Risk Type | N/A |
| Main Result | Positive |
| Result | The data indicate that the increase in expression of ACKR3 gene by hypomethylation and the decrease in expression of APOE gene via hypermethylation are possibly involved in the onset and progression of inflammatory processes in MS patients. |
| Mechanism/Pathway | the methylation pattern of these genes can be involved in the onset and/or progression of inflammatory processes in MS. |
