Basic information of OGG1 :
| Official Symbol of Gene | OGG1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4968 |
| Official Full Name | 8-oxoguanine DNA glycosylase |
| Also known as | HMMH; MUTM; OGH1; HOGG1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000114026 MIM:601982; AllianceGenome:HGNC:8125 |
| Map Location | 3p25.3 |
| Variation Type | genotype |
| refSNP ID | Ser/Cys |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | Peripheral blood |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS,RPMS |
| Population | N/A |
| Sample Size | 113 unrelated MS patients and 135 matched healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26562193 |
| Year | 2015 |
| Title | The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | OGG1 Ser/Cys and Ser/Cys + Cys/Cys genotypes had higher MS risk. |
| Mechanism/Pathway | Since polymorphisms in DNA repair genes can result in reduced DNA repair capacity |
