Basic information of XRCC1 :
| Official Symbol of Gene | XRCC1 |
| Species | Homo sapiens |
| Entrez Gene ID | 7515 |
| Official Full Name | X-ray repair cross complementing 1 |
| Also known as | RCC; SCAR26 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000073050 MIM:194360; AllianceGenome:HGNC:12828 |
| Map Location | 19q13.31 |
| Variation Type | genotype |
| refSNP ID | Arg/Gln + Gln/Gln |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | Peripheral blood |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS,RPMS |
| Population | N/A |
| Sample Size | 113 unrelated MS patients and 135 matched healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26562193 |
| Year | 2015 |
| Title | The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | XRCC1 Arg/Gln +Gln/Gln genotype increased the risk of MS. |
| Mechanism/Pathway | Since polymorphisms in DNA repair genes can result in reduced DNA repair capacity |
