Basic information of TRB :
| Official Symbol of Gene | TRB |
| Species | Homo sapiens |
| Entrez Gene ID | 6957 |
| Official Full Name | T cell receptor beta locus |
| Also known as | TCRB; TRB@ |
| Gene Type | protein coding |
| dbXrefs | AllianceGenome:HGNC:12155 |
| Map Location | 7q34 |
| Variation Type | SNP |
| refSNP ID | Vβ6.1 |
Sample information of multiple sclerosis:
| Detected Sample | Blood samples |
| Sample Detail | peripheral blood cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | seven patients |
Literature information of multiple sclerosis :
| Pubmed ID | 1717998 |
| Year | 1991 |
| Title | Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | disease risk |
| Main Result | Positive |
| Result | The concurrent demonstration by others that T cells within demyelinating areas of multiple sclerosis brains preferentially express VP5.2 and V.86.1 suggests that the BP-specific clones derived from blood may be relevant to disease pathogenesis. |
| Mechanism/Pathway | peripheral blood T cells are a reflection of cells involved in the central nervous system damage and that BP reactivity is a component of the pathogenic response in MS. |
