Basic information of GSTT1 :
| Official Symbol of Gene | GSTT1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2952 |
| Official Full Name | glutathione S-transferase theta 1 |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | MIM:600436 |
| Map Location | 22q11.23 |
| Variation Type | genotype |
| refSNP ID | M1/T1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood sample |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Iranian |
| Sample Size | 270 patients and 250 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 29055472 |
| Year | 2017 |
| Title | Human glutathione s-transferase enzyme gene variations and risk of multiple sclerosis in Iranian population cohort |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The findings demonstrated a highly significant association between the null genotypes and MS (OR = 6.89 for M1/T1). |
| Mechanism/Pathway | According to this study, it can be proposed that people with GSTM1 and GSTT1 deletions are at a higher risk for developing MS, which can be due to a decrease in enzymatic activity and their levels in nerve cells and the brain. |
