Basic information of GSTM1 :
| Official Symbol of Gene | GSTM1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2944 |
| Official Full Name | glutathione S-transferase mu 1 |
| Also known as | MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134184 MIM:138350; AllianceGenome:HGNC:4632 |
| Map Location | 1p13.3 |
| Variation Type | genotype |
| refSNP ID | M1/T1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood sample |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Iranian |
| Sample Size | 270 patients and 250 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 29055472 |
| Year | 2017 |
| Title | Human glutathione s-transferase enzyme gene variations and risk of multiple sclerosis in Iranian population cohort |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | The null genotypes were found to be more frequent in women than in men. Moreover, a significant association was observed between the null genotype and EDSS 6–10 (OR = 3.199). |
| Mechanism/Pathway | According to this study, it can be proposed that people with GSTM1 and GSTT1 deletions are at a higher risk for developing MS, which can be due to a decrease in enzymatic activity and their levels in nerve cells and the brain. |
