Basic information of CIITA :
| Official Symbol of Gene | CIITA |
| Species | Homo sapiens |
| Entrez Gene ID | 4261 |
| Official Full Name | class II major histocompatibility complex transactivator |
| Also known as | C2TA; NLRA; MHC2TA; CIITAIV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179583 MIM:600005; AllianceGenome:HGNC:7067 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs4774 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Spanish |
| Sample Size | one in 22 multiple sclerosis patients with active human herpes virus 6 (HHV-6A) replication (HHV6A-positive), and the other of 77 patients with no detectable HHV-6A active infection (HHV-6Anegative); a Spanish healthy control group (n = 520) |
Literature information of multiple sclerosis :
| Pubmed ID | 17678724 |
| Year | 2007 |
| Title | Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We then analyzed the combinations of genotypes formed by those two markers, which were in moderate linkage disequilibrium in our population, and multivariate analysis suggested that it depended more on rs4774 than on rs3087456. |
| Mechanism/Pathway | This would result in viral activation that in turn might underlie some cases of MS. |
