Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs6897932(CC) |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood samples |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS, PRMS |
| Population | Kerala, India |
| Sample Size | MS patients (n = 81) and healthy individuals (n = 82) |
Literature information of multiple sclerosis :
| Pubmed ID | 33657520 |
| Year | 2021 |
| Title | Class II HLA (DRB1, & DQB1) alleles and IL7R (rs6897932) variants and the risk for Multiple Sclerosis in Kerala, India |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Univariate analysis of IL7R SNP (rs6897932) showed no significant association with MS in our population whereas analysis of HLA-DRB1 alleles and IL7R (rs6897932) genotypes showed significant association between the HLA-DRB1*15:01/15:02 and the IL7R (rs6897932) CC genotype (OR = 3.58, p = 0.0002). |
| Mechanism/Pathway | N/A |
