Basic information of PTPN22 :
| Official Symbol of Gene | PTPN22 |
| Species | Homo sapiens |
| Entrez Gene ID | 26191 |
| Official Full Name | protein tyrosine phosphatase non-receptor type 22 |
| Also known as | LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134242 MIM:600716; AllianceGenome:HGNC:9652 |
| Map Location | 1p13.2 |
| Variation Type | SNP |
| refSNP ID | 1858 SNP |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | Spanish |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 15765267 |
| Year | 2005 |
| Title | Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | In conclusion, our data suggest that the PTPN22 1858 SNP has no, or only a negligible effect on MS susceptibility in the Spanish population. However, a minor effect of the PTPN22 SNP cannot be ruled out, and this may only be verifiable in an extremely large data set. |
| Mechanism/Pathway | The lymphoid-specific phosphatase (LYP), encoded by the PTPN22 gene, is important in negative control of T-cell activation and in T-cell development. |
