Basic information of ITGA4 :
| Official Symbol of Gene | ITGA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 3676 |
| Official Full Name | integrin subunit alpha 4 |
| Also known as | IA4; CD49D |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115232 MIM:192975; AllianceGenome:HGNC:6140 |
| Map Location | 2q31.3 |
| Variation Type | SNP |
| refSNP ID | Rs1449263 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Basque Country in northern Spain, Nordic countries |
| Sample Size | Basque Country in northern Spain (352 patients; 235 controls) and Nordic countries (1119 patients; 1235 controls) |
Literature information of multiple sclerosis :
| Pubmed ID | 17689671 |
| Year | 2007 |
| Title | ITGA4 polymorphisms and susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Carriage of the C allele of the ITGA4 promoter SNP rs1449263 was independently and weakly increased in MS patients from each population compared to respective controls (P= 0.037 in Basque; and P= 0.042 in Nordic cohorts), though these associations were lost upon application of permutation correction. |
| Mechanism/Pathway | N/A |
