Basic information of CYBB :
| Official Symbol of Gene | CYBB |
| Species | Homo sapiens |
| Entrez Gene ID | 1536 |
| Official Full Name | cytochrome b-245 beta chain |
| Also known as | CGD; CGDX; NOX2; IMD34; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000165168 MIM:300481; AllianceGenome:HGNC:2578 |
| Map Location | Xp21.1-p11.4 |
| Variation Type | SNP |
| refSNP ID | rs72619425 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | Sweden |
| Sample Size | MS (n 5 87), CIS (n 5 19), and OND (n 5 31) |
Literature information of multiple sclerosis :
| Pubmed ID | 27479807 |
| Year | 2016 |
| Title | TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We identified SNPs in the human NOX2 (CYBB) gene that associated with the severity of MS, and significantly increased CYBB expression was recorded in PBMCs from both MS patients and from MS severity risk allele rs72619425-A carrying individuals. |
| Mechanism/Pathway | N/A |
