Basic information of CD6 :
| Official Symbol of Gene | CD6 |
| Species | Homo sapiens |
| Entrez Gene ID | 923 |
| Official Full Name | CD6 molecule |
| Also known as | TP120 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000013725 MIM:186720; AllianceGenome:HGNC:1691 |
| Map Location | 11q12.2 |
| Variation Type | SNP |
| refSNP ID | rs17824933 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Real-Time PCR |
| Disease | MS |
| Disease subtype | PPMS, RRMS, SPMS, PRMS |
| Population | Spain |
| Sample Size | 2515 MS patients and 2942 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20430450 |
| Year | 2010 |
| Title | Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We demonstrate significant association of rs17824933 in CD6 (PCMH= 0.004; OR= 1.14; 95% CI 1.04–1.24) and of rs1860545 in TNFRSF1A (PCMH= 0.001; OR= 1.15; 95% CI 1.06–1.25) with MS. |
| Mechanism/Pathway | In addition, the soluble form of CD6 is capable of binding to various Gram-positive and -negative bacterial strains via recognition of pathogen-associated molecular patterns, and it downregulates serum levels of pro-inflammatory cytokines including IL-6, IL-1β and TNF-α upon challenge of mice with LPS. |
