Basic information of CD40 :
| Official Symbol of Gene | CD40 |
| Species | Homo sapiens |
| Entrez Gene ID | 958 |
| Official Full Name | CD40 molecule |
| Also known as | p50; Bp50; CDW40; TNFRSF5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000101017 MIM:109535; AllianceGenome:HGNC:11919 |
| Map Location | 20q13.12 |
| Variation Type | SNP |
| refSNP ID | rs4810485*T |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | B cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Caucasian descent(case) and Cambridge BioResource(control) |
| Sample Size | 68 patients and 162 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 29361022 |
| Year | 2018 |
| Title | Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Finally, we also observed that the risk allele rs4810485*T was associated with decreased levels of interleukin-10 (P = 0.020). |
| Mechanism/Pathway | It is considered to have an immunoregulatory function downstream of CD40. |
