Basic information of GAL :
| Official Symbol of Gene | GAL |
| Species | Homo sapiens |
| Entrez Gene ID | 51083 |
| Official Full Name | galanin and GMAP prepropeptide |
| Also known as | ETL8; GALN; GLNN; GMAP; GAL-GMAP |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000069482 MIM:137035; AllianceGenome:HGNC:4114 |
| Map Location | 11q13.2 |
| Variation Type | allele |
| refSNP ID | rs948854(G) |
Sample information of multiple sclerosis:
| Detected Sample | buccal epithelium samples |
| Sample Detail | nuclear DNA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | northern European region of the Russian Federation |
| Sample Size | 111 patients and 115 control subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 27870457 |
| Year | 2017 |
| Title | Single-nucleotide polymorphism rs948854 in human galanin gene and multiple sclerosis: a gender-specific risk factor |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The minor allele (G) increased susceptibility to MS in men. |
| Mechanism/Pathway | Although it remains to be determined whether A-to-G substitution in rs948854 reduces GAL transcription, a subsequent reduction in the galanin level, if confirmed, likely contributes to the increased susceptibility to MS, whereas testosterone may temporarily protect male carriers from MS onset. |
