Basic information of MTHFR :

Official Symbol of Gene	MTHFR
Species	Homo sapiens
Entrez Gene ID	4524
Official Full Name	methylenetetrahydrofolate reductase
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000177000 MIM:607093; AllianceGenome:HGNC:7436
Map Location	1p36.22
Variation Type	missense
refSNP ID	C677T

Sample information of multiple sclerosis:

Detected Sample	blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	Tunisian
Sample Size	80 multiple sclerosis patients and 200 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	23523621
Year	2013
Title	Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	No significant differences were found in the frequency of the MTHFR C677T polymorphism between MS patients and healthy controls.
Mechanism/Pathway	Methylenetetrahydrofolate reductase (MTHFR) is a folate dependent enzyme which regulates a key metabolic intersection in the folate pathway.