Basic information of SPP1 :
| Official Symbol of Gene | SPP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6696 |
| Official Full Name | secreted phosphoprotein 1 |
| Also known as | OPN; BNSP; BSPI; ETA-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000118785 MIM:166490; AllianceGenome:HGNC:11255 |
| Map Location | 4q22.1 |
| Variation Type | polymorphisms |
| refSNP ID | 5891C/T |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Japanese |
| Sample Size | patients with bronchial asthma (n = 268) and Healthy controls (n = 343) |
Literature information of multiple sclerosis :
| Pubmed ID | 16433860 |
| Year | 2006 |
| Title | Sequence variants of the secreted phosphoprotein 1 gene are associated with total serum immunoglobulin E levels in a Japanese population |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | Interestingly, individuals carrying the 5891C allele, which is more prevalent in patients with MS in Japanese populations, displayed significantly lower levels of total serum IgE. |
| Mechanism/Pathway | the SPP1 gene may represent a genetic factor that plays a role in basal IgE production in a nonantigen-specific (non-cognate) fashion. |
