Basic information of Il22ra2 :
| Official Symbol of Gene | Il22ra2 |
| Species | Rattus norvegicus |
| Entrez Gene ID | 444986 |
| Official Full Name | interleukin 22 receptor subunit alpha 2 |
| Also known as | Crf2-s1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000012259 AllianceGenome:RGD:1303169 |
| Map Location | 1p12 |
| Variation Type | SNP |
| refSNP ID | rs17066096 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood cells |
| Sample Detail | peripheral blood monocytes |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | The Dark Agouti (DA) rat |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 31292217 |
| Year | 2019 |
| Title | IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We show that monocytes from carriers of the risk genotype of rs17066096 express more IL-22BP in vitro and cerebrospinal fluid levels of IL-22BP correlate with MS lesion load on magnetic resonance imaging. |
| Mechanism/Pathway | We confirm the pathogenicity of IL-22BP in both rat and mouse models of MS and go on to suggest a pathogenic mechanism involving lack of IL-22–mediated inhibition of T cell–derived IFN-g expression. |
