Basic information of DDT :
| Official Symbol of Gene | DDT |
| Species | Homo sapiens |
| Entrez Gene ID | 1652 |
| Official Full Name | D-dopachrome tautomerase |
| Also known as | D-DT; DDCT; MIF2; MIF-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000099977 MIM:602750; AllianceGenome:HGNC:2732 |
| Map Location | 22q11.23 |
| Variation Type | SNP |
| refSNP ID | rs755622 |
Sample information of multiple sclerosis:
| Detected Sample | brain and blood samples |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 30140701 |
| Year | 2018 |
| Title | Genetic Variant rs755622 Regulates Expression of the Multiple Sclerosis Severity Modifier D-Dopachrome Tautomerase in a Sex-Specific Way |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Te results show that the minor allele frequency of rs755622 and expression of DDT are signifcantly increased in males for MS subjects and this minor allele variant can signifcantly upregulate DDT expression for males but not females, which suggests that the regulation of DDT expression level by rs755622 can afect MS progression in males. |
| Mechanism/Pathway | N/A |
