Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood samples |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | SPMS |
| Population | a multigenerational family |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 12076998 |
| Year | 2002 |
| Title | A multigenerational family with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A transmission disequilibrium test analysis was significant for the DRB1*15 allele within this single family. |
| Mechanism/Pathway | The inheritance pattern in this family suggests the presence of a single major locus responsible for multiple sclerosis susceptibility,with DBR1 acting as an important modifier. |
