Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | polymorphisms |
| refSNP ID | DRB1*15 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood leukocytes |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | PPMS, RRMS |
| Population | SPanish |
| Sample Size | 268 patients and 1088 unrelated healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21418440 |
| Year | 2011 |
| Title | Association of HLA-DRB1*15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort |
Results of multiple sclerosis :
| Risk Type | Phenotype risk |
| Main Result | Positive |
| Result | HLA-DRB1*15 allele is associated with OCB-positive patients with MS when studying a Spanish MS population |
| Mechanism/Pathway | This hypothesis may be supported by previous published results in which DRB1*1501 patients showed elevated levels of inflammation in CSF, such as higher IgG synthesis levels, matrix metalloproteinase-9 activity, and an altered T-cell activation status. |
