Basic information of IL21 :
| Official Symbol of Gene | IL21 |
| Species | Homo sapiens |
| Entrez Gene ID | 59067 |
| Official Full Name | interleukin 21 |
| Also known as | Za11; IL-21; CVID11 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000138684 MIM:605384; AllianceGenome:HGNC:6005 |
| Map Location | 4q27 |
| Variation Type | SNP |
| refSNP ID | rs2055979 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RFLP-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 70 patients / 110 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26155434 |
| Year | 2015 |
| Title | Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | Our results showed that IL-21 rs2055979 (G/T) T allele positive (TT+GT) MS patients had lower disease progression compared to rs2055979 T allele negative (GG) patients. |
| Mechanism/Pathway | Along with TH1 cells, IL-17-producing CD4+ T cells (TH-17) play important roles in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of MS which are also found at high frequency in active MS lesions.IL-21, IL-6 and IL-22 are the other products of TH17 cells which also may involve in the disease process.IL-21 is a potent immunomodulatory cytokine with pleiotropic effects on both innate and adaptive immune responses.This cytokine enhances proliferation of lymphoid cells, increases cytotoxicity of CD8+ T cells and natural killer cells, and differentiation of B cells into plasma cells.IL-21 is found to synergize with TGF-β to induce RORγt and IL-17 in naive T cells and thereby augments the differentiation of Th17 cell, which also secrete IL-21, indicating that IL-21 auto-regulates its own production. |
