Basic information of IL16 :
| Official Symbol of Gene | IL16 |
| Species | Homo sapiens |
| Entrez Gene ID | 3603 |
| Official Full Name | interleukin 16 |
| Also known as | LCF; NIL16; PRIL16; prIL-16 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000172349 MIM:603035; AllianceGenome:HGNC:5980 |
| Map Location | 15q25.1 |
| Variation Type | SNP |
| refSNP ID | rs4072111 |
Sample information of multiple sclerosis:
| Detected Sample | EDTA anticoagulated peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Iranian |
| Sample Size | 250 MS patients / 400 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28151028 |
| Year | 2023 |
| Title | RETRACTED ARTICLE: The Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The IL-16 rs4072111C/T genotype and allele frequencies showed significantly differences between MS patients and controls.The genotype frequencies of the rs4072111C/T were 62% CC, 30.8% CT, and 7.2% TT in MS patients and were 79% CC, 18% CT, and 3% TT in the control groups.Allele frequencies of C and T alleles were 77.4% and 22.6% for MS patients, and 88% and 12% for control subjects, respectively. |
| Mechanism/Pathway | Interleukin-16 (IL-16), a pleiotropic cytokine, is an important regulator of T-cell activation which plays a key role in autoimmune diseases. Single-nucleotide polymorphisms (SNPs) in the IL-16 gene may lead to altered cytokine expression or biological activity, and these variations may modulate an individual’s risk for MS. |
