Basic information of IL16 :
| Official Symbol of Gene | IL16 |
| Species | Homo sapiens |
| Entrez Gene ID | 3603 |
| Official Full Name | interleukin 16 |
| Also known as | LCF; NIL16; PRIL16; prIL-16 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000172349 MIM:603035; AllianceGenome:HGNC:5980 |
| Map Location | 15q25.1 |
| Variation Type | SNP |
| refSNP ID | rs11556218 |
Sample information of multiple sclerosis:
| Detected Sample | EDTA anticoagulated peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Iranian |
| Sample Size | 250 MS patients / 400 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28151028 |
| Year | 2023 |
| Title | RETRACTED ARTICLE: The Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Statistically significant differences were also found in allele and genotype frequencies of rs11556218 G/T between two groups.In MS patients, the genotype frequencies of rs11556218T/G were 32.8% for TT, 59.2% for TG, and 8% for GG and were 54% for TT, 42% for TG, and 4% for GG in healthy controls.Allele frequencies of T and G alleles were 62.4% and 37.6% for MS patients, and 75% and 25% for control subjects, respectively. |
| Mechanism/Pathway | Interleukin-16 (IL-16), a pleiotropic cytokine, is an important regulator of T-cell activation which plays a key role in autoimmune diseases. Single-nucleotide polymorphisms (SNPs) in the IL-16 gene may lead to altered cytokine expression or biological activity, and these variations may modulate an individual’s risk for MS. |
