Basic information of NINJ2 :
| Official Symbol of Gene | NINJ2 |
| Species | Homo sapiens |
| Entrez Gene ID | 4815 |
| Official Full Name | ninjurin 2 |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000171840 MIM:607297; AllianceGenome:HGNC:7825 |
| Map Location | 12p13.33 |
| Variation Type | SNP |
| refSNP ID | rs7298096 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 205 RRMS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 35912872 |
| Year | 2022 |
| Title | Interdependency of NINJ2 gene expression and polymorphism with susceptibility and response to interferon beta in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Positive |
| Result | The distribution of rs7298096 SNP was significantly different in the responders and non-responder patients and the NINJ2 gene expression considerably increased in the non-responder patients compare to the responders.The NINJ2 gene expression level in the AA genotype of the non-responder group was higher than to the other genotypes of both groups. |
| Mechanism/Pathway | According to a genomewide association study (GWAS) with 4-year follow-up that performed on RRMS patients, the rs7298096 polymorphism in the NINJ2 gene was shown the strong association with IFN-β response.The NINJ2 encodes for Ninjurin-2 protein, which is a cell surface adhesion protein, and as its paralogue, NINJ1 plays a role in nerve regeneration, inflammation, and endothelial cell activation. |
