Basic information of SLC6A4 :
| Official Symbol of Gene | SLC6A4 |
| Species | Homo sapiens |
| Entrez Gene ID | 6532 |
| Official Full Name | solute carrier family 6 member 4 |
| Also known as | HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000108576 MIM:182138; AllianceGenome:HGNC:11050 |
| Map Location | 17q11.2 |
| Variation Type | polymorphisms |
| refSNP ID | 5-HTTLPR, rs35521, and STin2VNTR |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | Iranian |
| Sample Size | 100 MS patients / 100 healthy individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 30886676 |
| Year | 2018 |
| Title | Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequencies of alleles, genotypes, genotype combinations, and haplotypes did not differ significantly between patients with MS and healthy controls. |
| Mechanism/Pathway | Serotonin (5-hydroxytryptamine) plays a pivotal role in the pathophysiology of most neuropsychiatric disorders.Serotonin level itself is controlled by serotonin reuptake transporter (SERT) gene on chromosome 17q11.2, and different polymorphisms affect the transcription activity of this gene, leading to impaired serotonin reuptake. |
