Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs6897932 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | Turkish |
| Sample Size | 298 MS patients / 307 healthy individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 33354118 |
| Year | 2019 |
| Title | Assessment of IL-7RA T244I Polymorphism as a Risk Factor of Multiple Sclerosis in Turkish Population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | In our study, there were no significant differences in genotype frequencies in the IL-7RA rs6897932 polymorphism and no significant difference between C and T alleles in patients with MS and controls. |
| Mechanism/Pathway | An enormous amount of research has shown that immune mediators such as cytokines and chemokines are the culprits of MS pathophysiology.There are several lines of evidence indicating that the receptor of interleukin (IL)-7 is associated with the risk of MS. The IL-7 receptor (IL-7R) gene is located on the short arm of chromosome 5 at position 13 (5p13), consisting of a γ-chain (IL7Rγ) and an α-chain (IL7-RA).As the T244I variant of the IL-7RA gene,rs6897932 is considered to be the strongest single-nucleotide polymorphism (SNP) associated with MS. |
