Basic information of IL25 :

Official Symbol of Gene	IL25
Species	Homo sapiens
Entrez Gene ID	64806
Official Full Name	interleukin 25
Also known as	IL17E
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000166090 MIM:605658; AllianceGenome:HGNC:13765
Map Location	14q11.2
Variation Type	polymorphisms
refSNP ID	c424C/A

Sample information of multiple sclerosis:

Detected Sample	peripheral blood immune cells
Sample Detail	N/A
Detected Method	PCR-RFLP
Disease	MS
Disease subtype	N/A
Population	Iranian
Sample Size	74 patients with MS / 75 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	28144453
Year	2016
Title	The Association Between C424c/A Polymorphism Within the IL-25 Gene and Multiple Sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	The results showed that there was no statistical significant difference in distribution of genotype (AA, AC and CC) and allele (A and C) frequencies between MS patients and healthy controls .
Mechanism/Pathway	This cytokine has a similar structure to IL-17 and plays a key role in stimulating and development of T helper 2 (Th2) responses.Furthermore, IL-25 is involved in the control function of endothelial cell, Th1 and Th17, which are the main cells involved in the pathogenic activities of the immune system. Therefore, any factor, which can regulate the expression of the cytokine, can be considered as a candidate for investigation in the MS disease process.