Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs6897932 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | ARMS-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Khuzestan |
| Sample Size | 127 MS patients / 109 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25422737 |
| Year | 2014 |
| Title | Association of interleukin 7 receptor gene polymorphism rs6897932 with multiple sclerosis patients in Khuzestan |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Results show that rs6897932 is significantly different in and controls, while compared genotypes based on gender has shown different results.Although T/T genotype has not seen in men suffering MS, it is 4 (3.6%) in the control group. |
| Mechanism/Pathway | IL7Rα functions as a receptor for two signaling cascades: IL7 and thymic stromal lymphopoietin.In the IL7 pathway, IL7 interacts with IL7Rα and the gamma chain (γc) (CD132), forming the signaling complex.The IL7/IL7RA interaction is important for the maintenance of memory T-cells and the development, proliferation, and survival of B- and T-cells, especially CD+ T-cells, which are present in inflammatory lesions of MS patients. |
