Basic information of IL10 :
| Official Symbol of Gene | IL10 |
| Species | Homo sapiens |
| Entrez Gene ID | 3586 |
| Official Full Name | interleukin 10 |
| Also known as | CSIF; TGIF; GVHDS; IL-10; IL10A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962 |
| Map Location | 1q32.1 |
| Variation Type | SNP |
| refSNP ID | rs1800871, rs1800872, and rs1800896 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood leukocytes |
| Sample Detail | N/A |
| Detected Method | real-time PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | Lithuania |
| Sample Size | 127 MS patients / 195 healthy volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 35741685 |
| Year | 2022 |
| Title | IL-10 Gene Polymorphisms and IL-10 Serum Levels in Patients with Multiple Sclerosis in Lithuania |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The IL-10 rs1800871, rs1800872, and rs1800896 genotype and allele frequencies did not significantly differ between the MS and control groups. |
| Mechanism/Pathway | Decreased IL-10 mRNA expression is observed at MS, which may be associated with promoter polymorphisms.IL-10 is an important cytokine regulator of the immune system, secreted mainly by macrophages and T lymphocytes.It is involved in the immune response to infectious and autoimmune diseases.IL-10 has an anti-inflammatory effect by reducing the production of immunoactive molecules (TNF-α, IFNγ, and IL-12) and inhibiting antigen-specific cytotoxic T cells.Since IL-10 may have an inflammatory function, it activates B cells and promotes autoantibody production.In the absence of IL-2, it inhibits T-cell apoptosis and promotes T-cell growth . It has been shown to increase the productivity of IL-10-producing cells. |
