Basic information of GATA3 :

Official Symbol of Gene	GATA3
Species	Homo sapiens
Entrez Gene ID	2625
Official Full Name	GATA binding protein 3
Also known as	HDR; HDRS
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000107485 MIM:131320; AllianceGenome:HGNC:4172
Map Location	10p14
Variation Type	SNP
refSNP ID	rs3824662

Sample information of multiple sclerosis:

Detected Sample	whole blood
Sample Detail	N/A
Detected Method	real-time PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	106 MS patients / 113 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	33806248
Year	2021
Title	FOXP3 and GATA3 Polymorphisms, Vitamin D3 and Multiple Sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	No statistically significant genotypic and allelic differences were found in the distribution of GATA3 rs3824662 in the MS patients, compared with controls.
Mechanism/Pathway	In vivo and in vitro studies showed that GATA3 expression has a fundamental role in maintaining high-levels of Foxp3 in Tregs.GATA3 has been reported to prevent excessive polarization toward Th17 and inflammatory cytokine production of Treg cells.Indeed, GATA-3-null Treg cells have been shown to fail to maintain peripheral homeostasis and suppressive function, shifting toward Th17 cell phenotypes and expressing reduced amounts of Foxp3.