Basic information of PDCD1 :
| Official Symbol of Gene | PDCD1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5133 |
| Official Full Name | programmed cell death 1 |
| Also known as | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000188389 MIM:600244; AllianceGenome:HGNC:8760 |
| Map Location | 2q37.3 |
| Variation Type | SNP |
| refSNP ID | rs2227981 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 229 MS patients / 246 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 36308011 |
| Year | 2023 |
| Title | The association between PD-1 gene polymorphisms and susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Concerning PD-1.5 (+7785 C/T), the frequency of T allele carriers (TT + CT) was relatively higher in MS patients, which was marginally insignificant . |
| Mechanism/Pathway | Programmed cell death 1 (PD-1) is an immune checkpoint and has been reported to be associated with several autoimmune diseases. |
