Basic information of IL1B :
| Official Symbol of Gene | IL1B |
| Species | Homo sapiens |
| Entrez Gene ID | 3553 |
| Official Full Name | interleukin 1 beta |
| Also known as | IL-1; IL1F2; IL1beta; IL1-BETA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000125538 MIM:147720; AllianceGenome:HGNC:5992 |
| Map Location | 2q14.1 |
| Variation Type | SNP |
| refSNP ID | rs16944 |
Sample information of multiple sclerosis:
| Detected Sample | EDTA |
| Sample Detail | N/A |
| Detected Method | SSP-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iraqi |
| Sample Size | 68 RRMS patients / 133 control |
Literature information of multiple sclerosis :
| Pubmed ID | 32590124 |
| Year | 2020 |
| Title | Relapsing-remitting multiple sclerosis: A profile of interleukine-1 gene cluster polymorphisms in Iraqi patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result |
Under dominant model, IL1B |
| Mechanism/Pathway | The autoimmune inflammatory response in MS is initiated by autoreactive T lymphocytes that mount exaggerated immune responses against autoantigens of the CNS and promote inflammation, demyelination, gliosis and neuroaxonal degeneration.However, it has been demonstrated that lymphocyte migration across the blood–brain barrier is regulated by activation of proinflammatory cytokines, which showed upregulated levels in cerebrospinal fluid (CSF) and sera of MS patients.IL-1 is presented by super-family of immunomodulatory cytokines and natural antagonists that have pleiotropic effects and exert a prominent role in pathogenesis of several auto-inflammatory conditions including MS. IL1α and IL-1β, key members of IL-1 family, are proinflammatory mediators and their pathophysiological impact on the CNS and progression of chronic neurodegenerative diseases has been suggested.In MS, high levels of both cytokines have been found in white matter lesions, and accordingly, the impact of IL-1α and IL-1β on immunopathology of MS has been augmented. |
