Basic information of IL1B :

Official Symbol of Gene	IL1B
Species	Homo sapiens
Entrez Gene ID	3553
Official Full Name	interleukin 1 beta
Also known as	IL-1; IL1F2; IL1beta; IL1-BETA
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000125538 MIM:147720; AllianceGenome:HGNC:5992
Map Location	2q14.1
Variation Type	SNP
refSNP ID	rs1143634

Sample information of multiple sclerosis:

Detected Sample	EDTA
Sample Detail	N/A
Detected Method	SSP-PCR
Disease	MS
Disease subtype	RRMS
Population	Iraqi
Sample Size	68 RRMS patients / 133 control

Literature information of multiple sclerosis :

Pubmed ID	32590124
Year	2020
Title	Relapsing-remitting multiple sclerosis: A profile of interleukine-1 gene cluster polymorphisms in Iraqi patients

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	No association was found with IL1B+3962 variants.
Mechanism/Pathway	The autoimmune inflammatory response in MS is initiated by autoreactive T lymphocytes that mount exaggerated immune responses against autoantigens of the CNS and promote inflammation, demyelination, gliosis and neuroaxonal degeneration.However, it has been demonstrated that lymphocyte migration across the blood–brain barrier is regulated by activation of proinflammatory cytokines, which showed upregulated levels in cerebrospinal fluid (CSF) and sera of MS patients.IL-1 is presented by super-family of immunomodulatory cytokines and natural antagonists that have pleiotropic effects and exert a prominent role in pathogenesis of several auto-inflammatory conditions including MS. IL1α and IL-1β, key members of IL-1 family, are proinflammatory mediators and their pathophysiological impact on the CNS and progression of chronic neurodegenerative diseases has been suggested.In MS, high levels of both cytokines have been found in white matter lesions, and accordingly, the impact of IL-1α and IL-1β on immunopathology of MS has been augmented.