Basic information of IL1R1 :
| Official Symbol of Gene | IL1R1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3554 |
| Official Full Name | interleukin 1 receptor type 1 |
| Also known as | P80; IL1R; IL1RA; CD121A; D2S1473; IL-1RT1; IL-1R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115594 MIM:147810; AllianceGenome:HGNC:5993 |
| Map Location | 2q11.2-q12.1 |
| Variation Type | SNP |
| refSNP ID | rs2234650 |
Sample information of multiple sclerosis:
| Detected Sample | EDTA |
| Sample Detail | N/A |
| Detected Method | SSP-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iraqi |
| Sample Size | 68 RRMS patients / 133 control |
Literature information of multiple sclerosis :
| Pubmed ID | 32590124 |
| Year | 2020 |
| Title | Relapsing-remitting multiple sclerosis: A profile of interleukine-1 gene cluster polymorphisms in Iraqi patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Under dominant model, IL1R1pst1970CT + TT genotype was significantly associated with a decreased MS risk.IL1R1pst1 1970 T variant alleles were significantly decreased in MS patients compared to control. |
| Mechanism/Pathway | The autoimmune inflammatory response in MS is initiated by autoreactive T lymphocytes that mount exaggerated immune responses against autoantigens of the CNS and promote inflammation, demyelination, gliosis and neuroaxonal degeneration.However, it has been demonstrated that lymphocyte migration across the blood–brain barrier is regulated by activation of proinflammatory cytokines, which showed upregulated levels in cerebrospinal fluid (CSF) and sera of MS patients. Interleukin-1 receptor antagonist (IL1-RA) is the naturally occurring antagonist of IL-1α/IL-1β signaling pathways.It competitively inhibits both cytokines by binding the IL-1 receptor type I (IL-1R1). |
