Basic information of FCRL5 :
| Official Symbol of Gene | FCRL5 |
| Species | Homo sapiens |
| Entrez Gene ID | 83416 |
| Official Full Name | Fc receptor like 5 |
| Also known as | CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000143297 MIM:605877; AllianceGenome:HGNC:18508 |
| Map Location | 1q23.1 |
| Variation Type | SNP |
| refSNP ID | rs2012199 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | real-time PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Polish |
| Sample Size | 94 individuals with MS / 160 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 33889124 |
| Year | 2021 |
| Title | Variants of Novel Immunomodulatory Fc Receptor Like 5 Gene Are Associated With Multiple Sclerosis Susceptibility in the Polish Population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The CC genotype of rs2012199 has been identified only in individuals with MS.The CC and CT genotypes, as well as the C allele of rs2012199, were significantly more common in the MS subjects.We noted that decreased MS susceptibility was associated with the T allele rs2012199. |
| Mechanism/Pathway | The activation of B-cells and the mediation of the specific recognition of antigens by leukocytes are promoted by a large family of Fc receptors.Human FCRL5 (Fc receptor-like protein 5) is a novel IgG receptor of the immunoglobulin superfamily (IgSF), and its expression is mainly restricted to B-cells.In subjects with high neurodegeneration, some changes in the peripheral blood mononuclear cells (PBMCs), including lower FCRL5 expression and higher peripheral blood B-cells activation status—characterized by a down-regulation of B-cell-specific genes—have been noted. |
