Basic information of FCRL5 :
| Official Symbol of Gene | FCRL5 |
| Species | Homo sapiens |
| Entrez Gene ID | 83416 |
| Official Full Name | Fc receptor like 5 |
| Also known as | CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000143297 MIM:605877; AllianceGenome:HGNC:18508 |
| Map Location | 1q23.1 |
| Variation Type | SNP |
| refSNP ID | rs6679793 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | real-time PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Polish |
| Sample Size | 94 individuals with MS / 160 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 33889124 |
| Year | 2021 |
| Title | Variants of Novel Immunomodulatory Fc Receptor Like 5 Gene Are Associated With Multiple Sclerosis Susceptibility in the Polish Population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Similar results were obtained for the genotypes and alleles of rs6679793.The OR of MS in subjects with the AG genotype was equal to 0.28 and 0.23 in subjects with the GG genotype.Allele A was significantly more common in MS subjects.The OR of MS was significantly lower in the G allele group.We noted that decreased MS susceptibility was associated with the G allele rs6679793. |
| Mechanism/Pathway | The activation of B-cells and the mediation of the specific recognition of antigens by leukocytes are promoted by a large family of Fc receptors.Human FCRL5 (Fc receptor-like protein 5) is a novel IgG receptor of the immunoglobulin superfamily (IgSF), and its expression is mainly restricted to B-cells.In subjects with high neurodegeneration, some changes in the peripheral blood mononuclear cells (PBMCs), including lower FCRL5 expression and higher peripheral blood B-cells activation status—characterized by a down-regulation of B-cell-specific genes—have been noted. |
