Basic information of IL7R :

Official Symbol of Gene	IL7R
Species	Homo sapiens
Entrez Gene ID	3575
Official Full Name	interleukin 7 receptor
Also known as	ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024
Map Location	5p13.2
Variation Type	SNP
refSNP ID	rs11567685

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	PCR-RFLP
Disease	MS
Disease subtype	RRMS, SPMS, PPMS
Population	Iranian
Sample Size	219 patients / 258 unrelated matched healthy controls

Literature information of multiple sclerosis :

Pubmed ID	26221483
Year	2015
Title	Association study of four polymorphisms in the interleukin-7 receptor alpha gene with multiple sclerosis in Eastern Iran

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	Significant association was gained while the subtype stratification was applied on genotype level: for secondary-progressive multiple sclerosis (SPMS) in SNP rs11567685.Also allelic frequency of rs11567685 SNP showed a significant association for SPMS patients.Allelic analysis in the female group showed significant results for SPMS in SNP rs11567685 also this association was gained in the genotypic level of RR MS patients in the case of SNP rs11567685.
Mechanism/Pathway	Multiple sclerosis (MS) is a neurodegenerative disease in the central nervous system (CNS) that usually occurs in young adults.More than three decades after the apparition of susceptibility effect of HLA genes, the interleukin-7 receptor alpha chain (IL-7Ra) or (CD127) located on chromosome 5P13 was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus.IL-7Ra gene has crucial roles in some processes in the immune system such as development, maturation, and homeostasis of T and B cells.