Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs6897932 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | Iranian |
| Sample Size | 219 patients / 258 unrelated matched healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26221483 |
| Year | 2015 |
| Title | Association study of four polymorphisms in the interleukin-7 receptor alpha gene with multiple sclerosis in Eastern Iran |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Genotyping of SNP rs6897932 in SPMS of the male group demonstrated a significant statistical difference between cases. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a neurodegenerative disease in the central nervous system (CNS) that usually occurs in young adults.More than three decades after the apparition of susceptibility effect of HLA genes, the interleukin-7 receptor alpha chain (IL-7Ra) or (CD127) located on chromosome 5P13 was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus.IL-7Ra gene has crucial roles in some processes in the immune system such as development, maturation, and homeostasis of T and B cells. |
