Basic information of HSPA1A :

Official Symbol of Gene	HSPA1A
Species	Homo sapiens
Entrez Gene ID	3303
Official Full Name	heat shock protein family A (Hsp70) member 1A
Also known as	HSP70; HSP72; HSPA1; HSP70I; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1A; HEL-S-103
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000204389 MIM:140550; AllianceGenome:HGNC:5232
Map Location	6p21.33
Variation Type	SNP
refSNP ID	rs1061581

Sample information of multiple sclerosis:

Detected Sample	whole blood
Sample Detail	N/A
Detected Method	PCR-RFLP
Disease	MS
Disease subtype	RRMS
Population	Iranian
Sample Size	50 RRMS patients / 50 healthy control subjects

Literature information of multiple sclerosis :

Pubmed ID	30124009
Year	2019
Title	Heat Shock Protein 70 and The Risk of Multiple Sclerosis in The Iranian Population

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	Genotypic frequencies of HSP70 gene pointed to a non-significant association between polymorphism (AA/AG/GG) were observed at 0, genotype and presence of RRMS.We found no significant difference between RRMS patients and controls in the Iranian population based on the HSP70 variant.
Mechanism/Pathway	HSP70 have two physiological neuroprotective roles.In specific, they act as molecular chaperones that assist the proper folding of newly synthesized proteins, preventing protein aggregation, and degrading unstable and misfolded proteins.HSP70 may also act as a cytokine by stimulating a pro-inflammatory signal transduction cascade in monocytes.It has been proposed that in MS patients, overexpression of HSP70 proteins can protect the CNS from inflammation so that the CNS can help towards myelin repair.